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Genomics and Proteomics Population Genomics: The major focus is to decipher the genomic architectures of common diseases and to understand the genetic basis of inter-individual variability in response to drugs and vaccines. Principal Investigator: Partha P. Majumder miRNA mediated regulation in patients with chronic hepatitis B virus infection in immunotolerant and immunoactive phases: Understanding of the factors involved in Hepatitis B virus replication could lead to identification of potential target(s) for HBV therapeutic interventions for controlling disease progression. We aim to identify host factors and their miRNA mediated regulatory aspects that may have a significant affect on viral translational efficiency which ultimately determine the course of progression of the HBV mediated disease. Principal Investigator: Swati Subodh
Profiling the regulatory mechanisms in the viral and host genomes in Hepatitis B or Hepatitis C virus infections - A Functional Genomics Approach: Understanding the expression signatures, DNA methylation and micro RNA mediated gene expression control in determining the progression of disease in HBV and HCV infected individuals. The study also aims to explore the host factors involved in therapy non-responsiveness by a few of these individuals. Principal Investigator: Swati Subodh
Rapid Genotypic and mutational analysis of clinical HBV isolates using high throughput microarray technology and correlation with disease presentation, severity and outcomes: Whole genome profiling using microarray will enable not only genotype identification, but also delineation of mixed and recombinant types, in addition to identification of various mutations on a single chip in a single reaction set up. This information could be useful for clinicians in disease prognosis and patient management. The current project aims to design and develop such a microarray for HBV isolate characterization in the Indian population. Principal Investigator: Swati Subodh
Comprehensive proteomics profiling of CSF proteins from patients of different meningitis infections for biomarker discovery: This project is aimed at identifying protein biomarkers to accurately differentiate between meningitis of different origins. In that direction we intend to comprehensively study and analyze the cerebrospinal fluid (CSF) proteome of different meningitis types prevalent in India. CSF classified into various disease categories (bacterial, tubercular, fungal, parasitic, viral, non-infectious [seizures, febrile convulsions, hydrocephalus, neurodegenerative disorders) using stringent criteria (clinical, bacteriological, molecular) is subjected to comprehensive proteomics studies using latest high throughput separation and mass spectrometric technologies. This type of approach is expected to identify proteins which are up regulated or down regulated in the disease process and could act as possible markers. Principal Investigator: Somdutta Sen
Predictive markers for therapy response in metastatic Colorectal Cancer: Targeted gene expression profiling and mutation analysis: Aimed to profile gene expression and mutations of selected genes involved in EGF pathway to derive upon a set of genes that can be used as predictive markers to monitor drug response of Cetuximab treatment when used as first-line treatment in metastatic colorectal cancer (mCRC). The study will aim in arriving on strategies to increase median progression free survival and overall survival of patients with mCRC. Principal Investigator: Sujatha Sunil
Study of baseline BCR-ABL mutations in Indian Imatinib-naïve patients with newly diagnosed chronic phase CML: Validation of baseline BCR-ABL mutations that are present in Indian patients with chronic phase CML in order to evaluate therapy response of Imatinib. Principal Investigator: Sujatha Sunil Genetics of preeclampsia: Association studies involving genes in biological relevant pathways in Preeclampsia and eclampsia and utilizing placental gene expression profiling to study the pathophysiology, in developing gene signatures towards predicting the disease in the first trimester for effective surveillance and management. Principal Investigator: Binuja Varma
Role of BRCA1 and BRCA2 mutations in epithelial ovarian cancers: To study the role of founder mutations in tumour suppressor genes- BRCA1 and BRCA2 in epithelial ovarian cancer prognosis in Indian patients. Principal Investigator: Sujatha Sunil
Non-invasive strategies to detect mitochondrial genome variations: The study will be aimed towards the creation of a database of known/novel genome variations in the sample population. It will explore the significance of tissue specificity and sensitivity towards non-invasive strategies in the detection of mitochondrial genome variation. Profiling the mitochondrial DNA variations (SNPs, point and length Heteroplasmy, CNVs etc) will be done using viable platforms in these samples. Principal Investigator: Binuja Varma
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