Institute of Molecular Medicine

Institute of Molecular Medicine
International Biotech Park
Genesis Campus,
Phase II Opp Infosys,
Tal Mulshi Hinjewadi,
Pune 411057
Email: shankarram@immindia.org

Education
Ph.D Bundelkhand University, Jhansi, India (2002)
Masters of Organic Chemistry, Dr. B.R. Ambedkar University, Agra, India (1997)

2005-Present, Scientist, Institute of Molecular Medicine, Pune
2000-2005, Scientist, Lupin Research Park, Pune
1997-2000, Research Scientist, Ranbaxy Research Laboratory, Gurgaon
Our Lab is mainly focused on design and synthesis of novel molecules possessing anti-infective activity for development of newer drugs against variety of infectious and non-infectious diseases with the help of molecular modeling and other modern tools of drug designing. Primary research interest is in the area of Infectious diseases including Tuberculosis, HIV/AIDS, as well as other microbial pathogens like Malaria, Leishmaniasis, etc.

Design and synthesis of antimicrobial compounds

Under this research program, we are working in close collaboration with Professor Jyoti Chattopadhyaya (Bioorganic Chemistry, Uppsala University, Sweden) and the European Union.Project name: New approaches to target Tuberculosis, Call identifier: FP7-Health-2007-B) have identified a new class of molecules, which act successfully against multi-drug resistant mycobacteria. These molecules are a set of conformationally constrained hetrocyclics, which is truly new class of chemical structures, hitherto unknown. The in-vitro data against various Mycobacterium tuberculosis strains (sensitive, SDR strain, MDR strains and XDR strains) suggest that these molecules have considerable potential to be lead molecules against resistant and latent Mycobacterium tuberculosis strains for further therapeutic development.
Another ongoing project is on down-regulation of HIV/AIDS by using gene silencing approach (i.e. by Antisense and si-RNA approach). Thus, the present study intends to first identify novel siRNA targets for HIV-1 with special emphasis to subtype C followed by chemical modification of the nucleotides with unique chemistry to improve their therapeutic efficiency by enhancing their stability, delivery and binding to target RNA.

Upadhayaya, R. S., S. V. Lahore., M. P. Sarmah., V. Sharma., S. S. Dixit., P. D. Shinde., A. Y. Sayyed., A. M. Vibhute., M. M. Shaikh and J. Chattopadhyaya. Conformationally constrained Indeno[2,1-c] quinolines- A new class of anti-mycobacterial agents. Bioorganic & Medicinal Chemistry, BMC-S-0-01386

Upadhayaya, R. S., J. K. Vandavasi., M. P. Sarmah., R. A. Kardile., S. V. Lahore., A. M. Vibhute., S. S. Dixit., H. S. Deokar and Jyoti Chattopadhyaya.Novel Quinoline and Naphthalene derivatives as potent Anti-mycobacterial agents. Bioorganic & Medicinal Chemistry (manuscript under preparation)

Upadhayaya, R. S., G. M. Kulkarni., V. N. Rao., V. J. K., S. S. Dixit., V. Sharma and J. Chottopadhayaya 2009. Design, Synthesis and biological evaluation of novel triazole, urea and thiourea derivatives of Quinoline against Mycobacterium tuberculosis Bioorganic & Medicinal Chemistry Vol. 17, 4681-4692.

Upadhayaya, R. S., V. J. Kishore., V. N. Rao., V. Sharma., S. S. Dixit and J. Chattopadhaya. Design, Synthesis, Biological Evaluation and Molecular modeling studies of Novel Quinoline Derivatives Against Mycobacterium tuberculosis. Bioorganic Medicinal Chemistry

Sinha, N., S. Jain., A. Tilekar., R. S. Upadhayaya., N. Kishore., G. H. Jana and S. K. Arora 2005. Synthesis and antimycobacterial evaluation of nitroheterocyclic-based 1, 2,4-benzothiadiazines. Bioorganic & Medicinal Chemistry Letters, 15(6).1573-1576.

Kishore. N., N. Sinha., S. Jain., R. S. Upadhayaya., R. Chandra and S. K. Arora 2005. Synthesis of disubstituted- and deoxydisubstituted- derivatives of α -D- xylofuranose as anticancer agents. ARKIVOC (i) 65-74

Sinha. N., S. Jain., A. Tilekar., R. S. Upadhayaya., N. Kishore., R. K. Sinha and S. K, 2005. Synthesis and antimycobacterial activity of some N, N’-disubstituted isonicotinohydrazide derivatives. ARKIVOC (ii) 9-19

Kishore. N., S. Jain., N. Sinha., R. S. Upadhayaya., R. Chandra and S. K. Arora(2005). Synthesis of some new disubstituted-and deoxy risubstituted α-Dallofuranoses. ARKIVOC (iii) 156-164.

Sinha. N., S. Jain, A. Tilekar., R. S. Upadhayaya., N. Kishore., G. H. Jana and S. K. Arora 2005. Synthesis of isonicotinic acid N’-arylidene-N-[2-oxo-2-(4-aryl-piperazin-1-yl) ethyl]-hydrazides as antitubercular agents”. Bioorganic & Medicinal Chemistry Letters, Bioorganic & Medicinal Chemistry Letters, 15, 1573-1576

Upadhayaya R. S., S. Jain., N. Sinha., N. Kishore., R. Chandra and S. K. Arora. Synthesis of novel substituted tetrazoles having antifungal activity. Euro. J. Med. Chem. 2004, 39, 579–592.

Upadhayaya R. S., S. Jain., N. Sinha., N. Kishore., R. Chandra and S. K. Arora 2004. Optically active antifungal azoles: synthesis and antifungal activity of (2R,3S)-2-(2,4-difluorophenyl)-3-(5-{2-[4-aryl-piperazin-1-yl]-ethyl}-tetrazol-2-yl/1-yl)-[1,2,4]-triazol-1-yl-butan-2-ol. Bioorganic & Medicinal Chemistry, 12, 2225–2238

Arora S. K., N. Sinha., R. K. Sinha., R. Bateja., S. Sharma. and R. S. Upadhayaya 2004. Design, Synthesis, modeling and activity of novel anti tubercular compounds. In program and Abstracts of the 227th ACS National Meeting, Anaheim, CA, United States American Chemical Society, Washington, D.C. MEDI-063.

Arora, S. K., N. Sinha., S. Jain., R. S. Upadhayaya., G. H. Jana., A. Shankar and R. K. Sinha 2004. Antimycobacterial agents. Drug data Report, 26, 5.

Arora S. K., N. Sinha., R. K. Sinha., R. S. Upadhayaya., V. M. Modak. and A. Tilekar. A, Synthesis and in vitro antimycobacterial activity of a novel Anti TB composition LL 4858. Abstract F1115 (slide presentation) pp 212. In 44th Interscience conference on Anti microbial agents and chemotherapy 2004, at Washington DC.

Kanase, D. G., M. Kulkarni., S. S. Kadam., V. D. Kelkar and R. S. Upadhayaya 2004. Asian Synthesis, spectral and XRD studies on isomeric chelates of Strontium (II) and Barium (II) with Phthiocol and plumbagin. Journal of Chemistry, 2004, 16, 1630-1636.

Arora, S. K., N. Sinha., S. Jain., R. S. Upadhayaya., G. H. Jana., A. Shankar and R. K. Sinha 2004. Pyrrole derivatives as antimycobacterial compounds. US Patent Appl. # 10/497615.

R. S. Upadhayaya and Jyoti Chattopadhyaya 2008. Novel quoline, non-quinoline and conformationally constrained quinoline derivatives as anti-mycobacterial agents. Patent filed in India(117/CHE/2008) and US PCT Patent Appl 61/033,055, Jan.

Arora, S. K., N. Sinha., R. S. Upadhayaya. and R. K. Sinha 2004. .Novel antimycobacterial pharmaceutical composition. US Patent Application # 10/844922.

Arora, S. K., N. Sinha., S. Jain, R. S. Upadhayaya., G. H. Jana, A. Shankar and R. K. Sinha 2004. Pyrrole derivatives as antimycobacterial compounds. WO 2004026828 (2004) PCT Patent Appl.

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