Somdutta Sen, Ph.D
Institute of Molecular Medicine
254 Okhla Industrial Estate, Phase III
New Delhi: 110020, India
Phone: 011-41028710
Fax: 011-41028709
E-mail: somdutta@tcgaresearch.org

Education:
B.Sc.(Chemistry Hons.), St. Stephens College, University of Delhi (1992).
M.Sc. (Organic Chemistry), St. Stephens College, University of Delhi (1994).
Ph.D. (Synthetic Organic Chemistry), Dept. of Chemistry, University of Delhi (1998).

Career History:
Presently, Senior Research Scientist and Group Leader (Proteomics) at Institute of Molecular Medicine, New Delhi.
2005-2008, Research Scientist at Institute of Molecular Medicine, New Delhi.
2003-2005, Quick Hire Scientist Institute of Genomics and Integrative Biology (IGIB) CSIR, New Delhi.
1999-2003, Research Associate at Institute of Genomics and Integrative Biology, New Delhi.
1998-1999, Research Associate ,  Deptt. Of Chemistry, University of Delhi, New Delhi.

Awards and Honours:
Invited speaker at Asia Oceania Human Proteome Organization (AOHUPO) meet,  Hongkong (2007)
Received ‘Young Investigator’s Award’ in Gordon Research Conference on CAG repeat disorders, held in Italy May (2003).
Received ‘Young Investigator’s Award’ in Gordon Research Conference on CAG repeat disorders, held in USA, (2005).
Qualified "National Eligibility Test" (NET) for Research and Lectureship in Chemistry and Awarded with "Junior Research Fellowship by Council of scientific and industrial research (1994)
Awarded with "Senior Research Fellowship" of Council of scientific and Industrial research (1996-1999).
Qualified "Graduate Aptitude Test in Engineering" (GATE) in Chemistry with a percentile score of 91 (1994)
Received National Merit Certificate in Secondary School Examination.

Research interests:
Our lab is mainly focused towards biomarker discovery for different infectious diseases from biological fluids like plasma, serum, CSF etc.  I am the Principal investigator of a project sponsored by DBT titled Comprehensive proteomics profiling of CSF proteins from patients of different meningitis infections for biomarker discovery. This project is aimed at identifying protein biomarkers to accurately differentiate between meningitis of different origins. In that direction we intend to comprehensively study and analyze the cerebrospinal fluid (CSF) proteome of different meningitis types prevalent in India. CSF classified into various disease categories (bacterial, tubercular, fungal, parasitic, viral, non-infectious [seizures, febrile convulsions, hydrocephalus, neurodegenerative disorders) using stringent criteria (clinical, bacteriological, molecular) is subjected to comprehensive proteomics studies using latest high throughput separation and mass spectrometric technologies. This type of approach is expected to identify proteins which are upregulated or downregulated in the disease process and could act as possible markers.

I am actively participating as significant contributor in a NIH funded project titled’ Immune events, transcriptomics and biomarkers in hepatitis E pathogenesis. The present project proposes to study human patients with HEV-mediated fulminant hepatic failure (FHF), the most severe form of disease with high rates of mortality. The overall aim is to characterize the host response, including immune events and the expression of host genes in the liver, the primary target organ for infection. Further, the project aims to search for diagnostic biomarkers of acute self-limited and fulminant hepatitis E.

I am also Co-PI of two project (DST sponsored) projects on Functional Genomics and proteomics of stress responses in N2-fixing cyanobacteria.

Publications:
Singh, Meha., Paushali. Mukherjee, K. Narayanasamy, Reena. Arora, Somdutta.  Sen , Shashank. Gupta, K. Natarajan and Pawan. Malhotra 2009. Proteome analysis of Plasmodium falciparum extracellular secretory antigens at asexual blood stages reveals a cohort of  proteins with possible roles in immune modulation and signaling . Molecular and Cellular Proteomics, June.

Baweja, Renu., M. Zaman, Somdutta.  Sen, T. Das, W. N. Gade and Y. Singh 2007. Properties of   Bacillus anthracis spores prepared under various environmental conditions. Archives of Microbiology, Vol 189, No1.

Sen, Somdutta and  S. Pasha 2004. A rapid method of sequencing long synthetic peptide sequences by laser power variation in MALDI-ToF, using polyglutamine model peptide.  Biochemical and Biophys. Res. Commun. 320: 635.

Sen, Somdutta., D. Das, S. Pasha and S. K. Brahmachari 2003. Role of histidine interruptions in mitigating the pathological effects of long polyglutamine stretches in SCA1 ; A molecular approach.  Protein Science, 12(05).

Masand, G., S. Pasha and Somdutta Sen 2006.   Synthesis, conformational and pharmacological studies of glycosylated chimeric peptides of met - enkaphalin and FMRF-a. Brain research Bulletin 68 :329-334.

Brahmachari, S. K., D. Sharma, S. Sharma, S. Pasha, Somdutta. Sen and Q. Saleem 2000. Probing the polyglutamine puzzle in neurological disorders FEBS Letts.  472,167.

Passey, S., Somdutta. Sen and G.B.V.Subramanian 1998. Some aspects of Chemistry of lac resin Journal Indian Chemical Society, 75, 575

Sen, Somdutta., and G.B .V. Subramanian 1999. Decarboxylative- halogenation of aleuritic acid derivatives using N- hydroxy pyridine-2-thione and a halogen source. Indian Journal of Chemistry, 38B, 854

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