Surajit Ganguly, Ph.D.
Institute of Molecular Medicine,
254 Okhla Industrial Estate, Phase III
New Delhi: 110020, India.
Phone: 91-11-41028710
Fax: 011-41028709  


M.Sc, Calcutta University, Calcutta, India (1991).
Ph.D, Indian Institute of Chemical Biology, Calcutta, India (1997)

Career History:
2007-Present, Team Lead; Institute of Molecular Medicine, New Delhi, India.
2007, Research Scientist, Lab. of Immunology, National Eye Institute, NIH, USA.
2005-2007, Research Faculty, Department of Pharmacology & Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
2005-2007, Adjunct Scientist, Section on Neuroendocrinology, NICHD, National Institutes of Health, Bethesda, Maryland, USA.
2003 -2005, Staff Research Fellow, National Institutes of Health, Bethesda, Maryland, USA
1998- 2003, Visiting Post-Doctoral Fellow in the Laboratory of Developmental Neurobiology, Section on  Neuroendocrinology, NICHD, National Institutes of Health, Bethesda, Maryland, USA.
1998-1998, Research Associate in Dr. G. Nucifora’s Lab at Cardinal Bernadine Cancer Center, Loyola University Medical center, Maywood, Illinois, USA.

Major Awards:
“Award of Merit” for “Productivity and Cutting-edge Research”, Oct 31, 2002, National Institutes of Health, Maryland, USA.
Award of Research Fellowship from CSIR to conduct Doctoral research in India -1992.

Research Interests:
1) One of the research goals of my laboratory is to identify small-molecule translational markers that might ensure progress in understanding the relationship between the NMDA-modulated animal models and the symptoms associated with schizophrenia spectrum disorders. We are specifically interested in deciphering the role of acetate metabolism in neurons of the drug-induced animal models. The working hypothesis is based on an aberration in neuronal “acetate” homeostasis might lead to reduced neuronal functioning via defects in neuronal mitochondrial glutamate-based energy metabolism and myelin lipid synthesis/myelin maintenance. Our long-term goal is to develop “small-molecule” food supplements as novel mechanism-based treatment strategies for psychiatric disorders.

2) Another on-going project in my laboratory is to obtain novel molecular profile of breast cancer in the context of Indian population and to apply this knowledge to the early detection, diagnosis and therapy of breast cancer. The objective will be to provide the physicians new molecular diagnostic and therapeutic tools that will possibly improve the detection and treatment options irrespective of the types of breast tumors. Our strategy will be to use cell and molecular tools to derive a core non-coding RNA or miRNA panel and use it to perform selective analysis and /or validation on noninvasive (ductal carcinoma in situ), invasive (invasive ductal carcinoma), and metastatic breast cancer (bone, ovarian, brain metastasis). This will help us to derive novel expression signatures typical for each stage of breast cancer for epithelial, stromal, and endothelial cells which can be utilized for early detection and/or therapy of breast cancer.

Selected Publications:

Chatterjee M, Ganguly S, Srivastava M, Palit G. Effect of 'chronic' versus 'acute' ketamine administration and its 'withdrawal' effect on behavioural alterations in mice: Implications for experimental psychosis. Behav Brain Res. 2010 Aug 8. [Epub ahead of print]

Klein DC, Bailey MJ, Carter DA, Kim JS, Shi Q, Ho A, Chik C, Gaildrat P, Morin F, Ganguly S, Rath MF, Møller M, Sugden D, Rangel ZG, Munson PJ, Weller JL, Coon SL. Pineal function: Impact of microarray analysis. Mol Cell Endocrinol. 2010 Jan 27;314(2):170-83. (Review)

Bailey MJ, Coon SL, Carter DA, Humphries A, Kim JS, Shi Q, Gaildrat P, Morin F, Ganguly S, Hogenesch JB, Weller JL, Rath MF, Møller M, Baler R, Sugden D, Rangel ZG, Munson PJ, Klein DC.  Night/day changes in pineal expression of >600 genes: Central role of adrenergic/cAMP signaling. J Biol Chem. J Biol Chem. 2009 Mar 20;284(12):7606-22.

Pavlicek J, Coon SL, Ganguly S, Weller JL, Hassan SA, Sackett DL, Klein DC. Evidence that proline focuses movement of the floppy loop of arylalkylamine N-acetyltransferase (ec J Biol Chem. 2008 Mar 24 2008 May 23;283(21):14552-8.

Szewczuk LM, Saldanha SA, Ganguly S, Bowers EM, Javoroncov M, Karanam B, Culhane JC, Holbert MA, Klein DC, Abagyan R, Cole PA. De novo discovery of serotonin N-acetyltransferase inhibitors.J Med Chem. 2007 Nov 1;50(22):5330-8. Epub 2007 Oct 9

Ganguly S, Grodzki C, Sugden D, Møller M, Odom S, Gaildrat P, Gery I, Siraganian RP, Rivera J, Klein DC. Neural Adrenergic/Cyclic AMP Regulation of the Immunoglobulin E Receptor {alpha}-Subunit Expression in the Mammalian Pinealocyte: A Neuroendocrine/Immune Response Link? J Biol Chem. 2007 Nov 9;282(45):32758-64. Epub 2007 Aug 29

Hwang Y, Ganguly S, Ho A K., Klein DC, and Cole PA.  Enzymatic and Cellular Study of a Serotonin N-acetyltransferase Phosphopantetheine-Prodrug Bioorg. Med Chem . 2007 Mar 1;15(5):2147-55. Epub 2006 Dec 13.

Rath MF, Munoz E, Ganguly S, Morin F, Shi Q, Klein DC, Moller M. Expression of the Otx2 homeobox gene in the developing mammalian brain: embryonic and adult expression in the pineal gland. J Neurochem. 2006 Apr;97(2):556-66.

Ganguly S, Weller JL  , Ho A , Chemineau P,  Malpaux B,   Klein DC .
Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205. Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1222-7.

Zheng W, Zhang Z, Ganguly S, Weller JL, Klein DC, Cole PA.
Cellular stabilization of the melatonin rhythm enzyme induced by nonhydrolyzable phosphonate incorporation. Nature Struct Biol. 2003 Dec;10(12):1054-7.

Klein, D.C., Ganguly, S., Coon, S.L., Weller, J.L.,  Shi, Q.,  Gaildrat, P., Morin, F.,  Weller, J. L. Obsil, T., Hickman, A. and Dyda, F.  14-3-3 Proteins in pineal photoneuroendocrine transduction: How many roles? Journal of Neuroendocrinology (2003) 85: 851-60.

Ganguly S, Coon SL, Klein DC. Control of melatonin synthesis in the mammalian pineal gland: the critical role of serotonin acetylation. Cell Tissue Res. 2002 Jul;309(1):127-37.

Ganguly S, Mummaneni P, Steinbach PJ, Klein DC, Coon SL. Characterization of the Saccharomyces cerevisiae Homolog of the Melatonin Rhythm Enzyme  Arylalkylamine N-Acetyltransferase (EC J Biol Chem 2001 Dec 14;276(50):47239-47247.

Ganguly S, Gastel JA, Weller JL, Schwartz C, Jaffe H, Namboodiri MA, Coon SL, Hickman AB, Rollag M, Obsil T, Beauverger P, Ferry G, Boutin JA, Klein DC.  Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis.  Proc Natl Acad Sci U S A 2001 Jul 3;98(14):8083-8088

Obsil T, Ghirlando R, Klein DC, Ganguly S, Dyda F.  Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation. Cell 2001 Apr 20;105(2):257-267

Chakrabarti SR, Sood R, Ganguly S, Bohlander S, Shen Z, Nucifora G. Modulation of TEL transcription activity by interaction with the ubiquitin-conjugating enzyme UBC9.  Proc Natl Acad Sci U S A 1999 Jun 22;96(13):7467-7472


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