Institute of Molecular Medicine

Institute of Molecular Medicine,
254 Okhla Industrial Estate, Phase III
New Delhi: 110020, India.
Phone: 91-11-41028710
Fax: 011-41028709
E-mail: surajitg@immindia.org
M.Sc, Calcutta University, Calcutta, India (1991).
Ph.D, Indian Institute of Chemical Biology, Calcutta, India (1997)

2007-Present, Team Lead; Institute of Molecular Medicine, New Delhi, India.
2007, Research Scientist, Lab. of Immunology, National Eye Institute, NIH, USA.
2005-2007, Research Faculty, Department of Pharmacology & Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
2005-2007, Adjunct Scientist, Section on Neuroendocrinology, NICHD, National Institutes of Health, Bethesda, Maryland, USA.
2003 -2005, Staff Research Fellow, National Institutes of Health, Bethesda, Maryland, USA
1998- 2003, Visiting Post-Doctoral Fellow in the Laboratory of Developmental Neurobiology, Section on Neuroendocrinology, NICHD, National Institutes of Health, Bethesda, Maryland, USA.
1998-1998, Research Associate in Dr. G. Nucifora’s Lab at Cardinal Bernadine Cancer Center, Loyola University Medical center, Maywood, Illinois, USA.

Major Awards:
“Award of Merit” for “Productivity and Cutting-edge Research”, Oct 31, 2002, National Institutes of Health, Maryland, USA.
Award of Research Fellowship from CSIR to conduct Doctoral research in India -1992.
Research Support Member: Ms. Preeti Koli (Research Associate)

Research Interests:
1) One of the research goals of my laboratory is to identify small-molecule translational markers that might ensure progress in understanding the relationship between the NMDA-modulated animal models and the symptoms associated with schizophrenia spectrum disorders. We are specifically interested in deciphering the role of acetate metabolism in neurons of the drug-induced animal models. The working hypothesis is based on an aberration in neuronal “acetate” homeostasis might lead to reduced neuronal functioning via defects in neuronal mitochondrial glutamate-based energy metabolism and myelin lipid synthesis/myelin maintenance. Our long-term goal is to develop “small-molecule” food supplements as novel mechanism-based treatment strategies for psychiatric disorders.

2) Another on-going project in my laboratory is to obtain novel molecular profile of breast cancer in the context of Indian population and to apply this knowledge to the early detection, diagnosis and therapy of breast cancer. The objective will be to provide the physicians new molecular diagnostic and therapeutic tools that will possibly improve the detection and treatment options irrespective of the types of breast tumors. Our strategy will be to use cell and molecular tools to derive a core non-coding RNA or miRNA panel and use it to perform selective analysis and /or validation on noninvasive (ductal carcinoma in situ), invasive (invasive ductal carcinoma), and metastatic breast cancer (bone, ovarian, brain metastasis). This will help us to derive novel expression signatures typical for each stage of breast cancer for epithelial, stromal, and endothelial cells which can be utilized for early detection and/or therapy of breast cancer.

Bailey MJ, Coon SL, Carter DA, Humphries A, Kim JS, Shi Q, Gaildrat P, Morin F, Ganguly S, Hogenesch JB, Weller JL, Rath MF, Møller M, Baler R, Sugden D, Rangel ZG, Munson PJ, Klein DC. J Biol Chem. 2009 Mar 20;284(12):7606-22.

Pavlicek, J., S. L. Coon, S. Ganguly, J. L. Weller, S. A. Hassan, D. L. Sackett, D. C. Klein. 2008 J Biol Chem 283(21):14552-8.

Szewczuk, M. L., S. A. Saldanha, S. Ganguly, E. M. Bowers, M. Javoroncov, B. Karanam, J. C. Culhane, M. A. Holbert, D. C. Klein, R. Abagyan, P. A. Cole. 2007. J Med Chem 50(22):5330-8.

Ganguly, S., C. Grodzki, D. Sugden, M. Møller, S. Odom S, P. Gaildrat, L. Gery, R. P. Siraganian, Rivera J, Klein DC. J Biol Chem. 2007 Nov 9;282(45):32758-64

Ganguly, S., J. L. Weller, A. Ho, P. Chemineau, B. Malpaux, D. C. Klein. (2005) Proc Natl Acad Sci U S A 102(4):1222-7.

Zheng, W., Z. Zhang, S. Ganguly, J. L. Weller, D. C. Klein, P. A. Cole. (2003) Nature Struct Biol 10(12):1054-7.

Ganguly, S., P. Mummaneni, P. J. Steinbach, D. C. Klein and S. L. Coon. (2001) J Biol Chem 276(50):47239-47247.

Ganguly, S., J. A. Gastel. 2001 et.al (2001) Proc Natl Acad Sci U S A. 98(14):8083-8088

Obsil, T., R. Ghirlando, D. C. Klein , S. Ganguly. Dyda F. (2001) Cell 105(2):257-267

Chakrabarti, S. R., R. Sood, S. Ganguly, S. Bohlander, Z. Shen, G. Nucifora. (1999) Proc Natl Acad Sci U S A 96(13):7467-7472.

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