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Swati Subodh, Ph.D.  Institute of Molecular Medicine254 Okhla Industrial Estate, Phase III New Delhi: 110020, India Phone: 011-41028710 Fax: 011-41028709 Mobile: 9810586532 E-mail: swatisubodh@tcgaresearch.org Education: Ph.D. All India Institute of Medical Sciences, New Delhi, India (2001-2006). M.Sc. (Biochemistry), Department of Biochemistry, Jamia Hamdard, New Delhi, India (1998-2000). Post Graduate Diploma (Biochemical Technology), Department of Biochemical Technology, Sri Venkateswara College, University of Delhi, New Delhi, India (1997-1998). B.Sc. (Biochemistry), Department of Biochemistry, Sri Venkateswara College, University of Delhi, New Delhi-110021, India (1994-1997). Awards Grant award under the FAST TRACK Scheme for Young Scientists by the Department of Science and Technology (DST), Ministry of Science and Technology, Govt. of India, (2009). Rapid Grant for Young Investigators by Department of Biotechnology (DBT), Ministry of Science and Technology, Govt. of India (2007). Senior Research Fellowship from Council of Scientific and Industrial Research (CSIR), Government of India. Awarded Lecturer ship by the Council for Scientific and Industrial Research/ University Grant Commission (CSIR-UGC) by qualifying the National Eligibility Test (N.E.T.) examination. Society Membership Full Member of the American Society for Virology (ASV) Ordinary member of the Society of Biological Chemists of India (SBC) Research Interests: miRNA mediated regulation in patients with chronic hepatitis B virus infection in immunotolerant and immunoactive phases: High number of chronic hepatitis B virus (HBV) infected patients in immunotolerant phase progress spontaneously to immunoactive phase. About 25% of the chronically infected patients develop HBV mediated liver complications later in life. Understanding of the factors involved in Hepatitis B virus replication could lead to identification of potential target(s) for HBV therapeutic interventions for controlling disease progression. We aim to identify host factors and their miRNA mediated regulatory aspects that may have a significant affect on viral translational efficiency which ultimately determine the course of progression of the HBV mediated disease. Profiling the regulatory mechanisms in the viral and host genomes in Hepatitis B or Hepatitis C virus infections- A Functional Genomics Approach: Understanding the expression signatures, DNA methylation and micro RNA mediated gene expression control in determining the progression of disease in HBV and HCV infected individuals. The study also aims to explore the host factors involved in therapy non-responsiveness by a few of these individuals. Rapid Genotypic and mutational analysis of clinical HBV isolates using high throughput microarray technology and correlation with disease presentation, severity and outcomes: Whole genome profiling using microarray will enable not only genotype identification, but also delineation of mixed and recombinant types, in addition to identification of various mutations on a single chip in a single reaction set up. This information could be useful for clinicians in disease prognosis and patient management. The current project aims to design and develop such a microarray for HBV isolate characterization in the Indian population. Patents Tuteja A., Narayanasamy K., and Subodh S. Identification of genomic signature for differentiating highly similar sequence variants of an organism’ (Manuscript under preparation). Tuteja A., Acharya S.K., Siddique A.B., Madan K., Narayanasamy K., Subodh S. Mutation profiling of hepatitis B virus in North Indian population. (Manuscript under presentation). * Sohal J.S, Sheoran N, Narayanasamy K, Brahmachari V, Singh SV and Subodh S. Genomic analysis of local isolate of Mycobacterium avium subspecies paratuberculosis J Vet Microbiol 2009; 134: 375-382. Nelson EA, Bresee JS, Parashar UD, Widdowson MA, Glass RI; Asian Rotavirus Surveillance Network (Fang ZY, Wang B, Zhang LJ, Sun LW, Du ZQ, Tang JY, Hou AC, Shen H, Song XB, Wang XY, Xu ZY, Zhang YL, Zhao SJ, Hao ZY, Xing ZC, Han CQ, Ma JC, Chen JC, Tam JS, Chan PK, Yu LM, Ng YC, Poon KH, Ng CH, Ip KS, Fok TF, Bahl R, Ray P, Subodh S, et al., ). Rotavirus epidemiology: the Asian Rotavirus Surveillance Network. Vaccine. 2008 Jun 19;26(26):3192-6. Singh SV, Singh PK, Singh AV, Sohal JS, Subodh S, Narayanasamy K. Non-chemical method of DNA recovery and characterization of Mycobacterium avium subspecies paratuberculosis using IS 900 PCR. Indian J Exp Biol. 2007 Sep;45(9):812-6. Sohal JS, Singh SV, Subodh S, Sheoran N, Narayanasamy K, Singh PK, Singh AV, Maitra A. Mycobacterium avium subspecies paratuberculosis diagnosis and geno-typing: Genomic insights. Microbiol Res. 2007 May 22. Subodh S, Bhan M.K., Ray P. Genetic Characterization of VP3 gene of Group A Rotaviruses. Virus Genes 2006; 33: 143-145. Bahl R., Ray P., Subodh S., Shambharkar P., Saxena M., Parashar U., Gentsch J., Glass R., and Bhan M.K. Incidence of severe rotavirus diarrhea in Delhi and the G and P types of the infecting. J Infect Dis. 2005 Sep 1;192 Suppl 1:S114-9. Ray P., Fenaux M., Sharma S., Malik J., Subodh S., Bhatnagar S., Greenberg H., Glass R.I., Gentsch J., and Bhan M.K. Quantitative evaluation of rotaviral antigenemia in children with acute rotaviral diarrhea. J Infect Dis. 2006 Sep 1;194(5):588-93. Subodh S., Ray P., Bhan M.K. Study of Rotavirus Structural Protein with respect to Sequence Diversity. J Clin Virol 2003 (Vol 27) Suppl 1: 64. Popular Articles Subodh S. Technology Scenario in India for Life Science Research: Challenges and Opportunities. Souvenir published and distributed at the Indian Analytical Instruments Association 2009 meeting on September 26, 2009 at Hyderabad, India. BookRay, M., S. Subodh, M. Joon and K. Narayanasamy, 2009 Comparative analysis of the copy number and position of insertion element IS6110 of Mycobacterium tuberculosis clinical isolates. Submitted to World Scientific Publishers. | 
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