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Institute of Molecular Medicine
254 Okhla Industrial Estate, Phase III
New Delhi: 110020, India
Phone: 011-41028710
Fax: 011-41028709
Mobile: 9810586532
E-mail: swatisubodh@tcgaresearch.org
The current research focus is the study of infectious diseases and understanding their regulatory aspects in terms of genomic modifications. Chronic Hepatitis B and Hepatitis C virus infections are a major cause of morbidity and development of cirrhosis and hepatocellular carcinoma. Failure of treatments and unpredictable disease progression continues to be a major area of concern. Understanding the genomic and epigenomic parameters of the host and the infecting pathogen offers a novel approach of understanding the infection and identification of potential drug targets.
Our group has developed genomic signatures for characterizing the infecting virus in clinical samples. We are now investigating the application of these signatures on host gene characterization by Mass spectrometry analysis. Additionally, we are investigating the micro RNA based regulation of gene expression in HBV mediated liver disease progression.
Genetic and epigenetic factors can be integrated using functional genomics and systems biology approach to get a better networked picture. This in turn holds application in the field of diagnostics and pharmacogenomics.
Research Scientist January 2010 to present
Institute of Molecular Medicine
Research Associate March 2006 to December 2009
Institute of Molecular Medicine
Research Assistant, July, 2000 – August 2001
All India Institute of Medical Sciences, New Delhi.
Ph.D., August, 2001 –February 2006
Advanced Center for Diarrheal Disease Research, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi-110029, India
Ph.D. thesis: Molecular Characterization of the NSP4 and VP3 genes of Rotavirus under the supervision of Prof. M.K.Bhan and co-supervision of Dr Pratima Ray, All India Institute of Medical Sciences, New Delhi, India.
M.Sc. [Biochemistry], August, 1998 – July, 2000.
Department of Biochemistry, Jamia Hamdard, New Delhi-110062, India
Post Graduate Diploma [Biochemical Technology], July 1997-July 1998.
Department of Biochemical Technology, Sri Venkateswara College, University of Delhi, New Delhi-110021, India
B.Sc. [Biochemistry], July, 1994 – June, 1997.
Department of Biochemistry, Sri Venkateswara College, University of Delhi, New Delhi-110021, India
Additional Qualification
Completed an Advanced Course on ‘Functional Genomics and Systems Biology’ by the Wellcome Trust Advance Courses, held at Wellcome Trust Genome Campus, Hinxton, Cambridge, UK in June-July 2007
- Awarded the “FEMS Congress Grant for Young Scientists” by the Federation of European Microbiological Societies in March 2011.
- Selected to participate in the US-India Joint Research Training Program Workshop to be held in January/February 2011. The workshop is funded in part by Fogarty International Center of the National Institutes of Health and Jawaharlal Nehru University for promising Junior Faculty.
- Grant award under the FAST TRACK Scheme for Young Scientists by the Department of Science and Technology (DST), Ministry of Science and Technology, Govt. of India, (2009).
- Rapid Grant for Young Investigators by Department of Biotechnology (DBT), Ministry of Science and Technology, Govt. of India (2007).
- Bursary Award by the Wellcome Trust, UK in 2005 and 2007
- Senior Research Fellowship from Council of Scientific and Industrial Research (CSIR), Government of India.
- Awarded Lecturer ship by the Council for Scientific and Industrial Research/ University Grant Commission (CSIR-UGC) by qualifying the National Eligibility Test (N.E.T.) examination.
Principal Investigator
‘miRNA mediated regulation in patients with chronic hepatitis B virus infection in immunotolerant and immunoactive phases’ funded by DST (2010-2013).
Collaborator: Grp Capt. Bhaskar Nandi, Army R&R Hospital, New Delhi.
Co-Principal Investigator
Connect to Decode Phase II – Cloning of M.tb genes funded by Open Source Drug Discovery (OSDD), CSIR (2010-2011).
Collaborator: Dr Anshu Bharadwaj, Scientist, Institute of Genomics & Integrative Biology, Delhi and Dr Vijayalakshmi Mahadevan, SASTRA University, Tamil Nadu.
Co-Investigator
‘Disease progression in patients with chronic Hepatitis B infection-A modeling and clinical investigation’ funded by DBT (2011-2014).
Collaborator: Dr Siddhartha Kundu, Asst. Professor, Army College of Medical Sciences, New Delhi and Dr Manoj Sharma, Asst. Professor, Institute of Liver & Biliary Sciences, New Delhi.
- Kundu S. and Subodh S. Chemical sensors for vectorial chemotaxis – a novel role for Reactive Oxygen Species. Int J Trends in Med (In press).
- * Tuteja A., Madan K., Siddique A.B., Logani JM, Kaur N., Subodh S. Mutation profiling of the Hepatitis B virus strains circulating in India. J Infectious Diseases. In Communication.
- Ahuja V., Subodh S., Tuteja A., Tiwari V., Kumar S, Gupta N., Narayanasamy K., Makharia G., and Acharya S.K. Genome wide gene expression analysis for target genes to differentiate patients with Intestinal tuberculosis and Crohn’s disease and discriminative value of FOXP3 mRNA expression. Intestinal Bowel Disease In Communication.
- * Subodh S., Datta S., Tuteja A., Parihar S., Madan K., Narayanasamy K. APOBEC3B polymorphism may not govern the viral susceptibility of individuals infected with Hepatitis B Virus. Ind J Med Res. In Communication
- * Tuteja A., Narayanasamy K., and Subodh S. Identification of genomic signature for differentiating highly similar sequence variants of an organism (manuscript under preparation).
- Verma P., Subodh S., Tuteja A., Ahuja V. Is Retinoic Acid the ‘Microenvironmental Cue’ for disease activity in patients with Ulcerative colitis? (Manuscript under preparation).
- * Subodh S., Verma R., Narayanasamy K., Kundu S*. Pharmacogenomics: A new facet in drug development and patient management. (Manuscript under preparation).
- * Sohal J.S, Sheoran N, Narayanasamy K, Brahmachari V, Singh SV and Subodh S. Genomic analysis of local isolate of Mycobacterium avium subspecies paratuberculosis J Vet Microbiol 2009; 134: 375-382.
- Nelson EA, Bresee JS, Parashar UD, Widdowson MA, Glass RI; Asian Rotavirus Surveillance Network (Fang ZY, Wang B, Zhang LJ, Sun LW, Du ZQ, Tang JY, Hou AC, Shen H, Song XB, Wang XY, Xu ZY, Zhang YL, Zhao SJ, Hao ZY, Xing ZC, Han CQ, Ma JC, Chen JC, Tam JS, Chan PK, Yu LM, Ng YC, Poon KH, Ng CH, Ip KS, Fok TF, Bahl R, Ray P, Subodh S, et al., ). Rotavirus epidemiology: the Asian Rotavirus Surveillance Network. Vaccine. 2008 Jun 19;26(26):3192-6.
- Singh SV, Singh PK, Singh AV, Sohal JS, Subodh S, Narayanasamy K. Non-chemical method of DNA recovery and characterization of Mycobacterium avium subspecies paratuberculosis using IS 900 PCR. Indian J Exp Biol. 2007 Sep;45(9):812-6.
- Sohal JS, Singh SV, Subodh S, Sheoran N, Narayanasamy K, Singh PK, Singh AV, Maitra A. Mycobacterium avium subspecies paratuberculosis diagnosis and geno-typing: Genomic insights. Microbiol Res. 2007 May 22.
- Subodh S, Bhan M.K., Ray P. Genetic Characterization of VP3 gene of Group A Rotaviruses. Virus Genes 2006; 33: 143-145.
- Bahl R., Ray P., Subodh S., Shambharkar P., Saxena M., Parashar U., Gentsch J., Glass R., and Bhan M.K. Incidence of severe rotavirus diarrhea in Delhi and the G and P types of the infecting. J Infect Dis. 2005 Sep 1;192 Suppl 1:S114-9.
- Ray P., Fenaux M., Sharma S., Malik J., Subodh S., Bhatnagar S., Greenberg H., Glass R.I., Gentsch J., and Bhan M.K. Quantitative evaluation of rotaviral antigenemia in children with acute rotaviral diarrhea. J Infect Dis. 2006 Sep 1;194(5):588-93.
(* corresponding author)
Indian Patent Application and PCT application (PCT/IN2009/000442) filed for the invention entitled ‘Identification of genomic signature for differentiating highly similar sequence variants of an organism’ on August 5, 2009 (Publication No. WO/2010/016071). Applicant: Dr Swati Subodh; Inventors: Amit Tuteja, Swati Subodh, K Narayanasamy.
2008-present: Nominated Member of the American Society for Virology (ASV)
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